迟春玲， 刘彬*
（ 哈尔滨医科大学附属第四医院神经内科，哈尔滨 150000； ）
摘要： ERK 是丝裂原活化蛋白激酶家族一员，其在将细胞外信号传给细胞元的反应中起重要作用，广泛地参与了复杂的生理病理过程。在中枢神经方面，目前研究发现ERK通路不仅在学习和记忆形成中发挥重要作用，而且也参与了脑缺血、痴呆、帕金森、肌萎缩侧索硬化症、癫痫等中枢神经系统常见疾病的发病过程。本文将重点阐述ERK通路在中枢神经系统疾病中国内外最新研究进展。
关键词： ERK传导通路；脑缺血；阿尔茨海默病；帕金森病；癫痫；生物学作用
Chi Chunling， Liu Bin*
（ Department of Neurology,The Fourth Affiliated Hospital of Harbin Medical University，Harbin 150000； ）
Abstract： ERK is one of mitogen activated protein kinase, and it plays an important role in transmitting the extracellular signals to the cell , widely involved in the complex physiological and pathological process. In the central nervous system, the present study found that the ERK pathway not only play an important role in learning and memory formation, but also involved in many common central nervous system diseases such as cerebral ischemia, dementia, Parkinson's disease, amyotrophic lateral sclerosis, epilepsya. This article will focus on the latest research progress of ERK pathway in the central nervous system diseases.
Keywords： ERK pathway;Cerebral ischemia; Alzheimer's disease; Parkinson's disease.;Epilepsy; Biological function
作者简介： 迟春玲（1982-），女，副主任医师，主要研究方向：脑血管病、血管性痴呆
通信联系人： 刘彬（1967-），男，主任医师，教授，主要研究方向：脑血管病、认知障碍、帕金森氏病
